{
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      "citation": "Hurd et al., NEJM 2013, Table 2",
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      "url": "https://diabetesjournals.org/care/article/47/1/26/153797/Economic-Costs-of-Diabetes-in-the-U-S-in-202",
      "citation": "ADA, Economic Costs of Diabetes 2022",
      "limit": "All diagnosed diabetes cost proxy for type 2. Score attenuation within families is not corrected.",
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      "name": "Prostate cancer",
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      "name": "Glaucoma",
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      "url": "https://pubmed.ncbi.nlm.nih.gov/34772873/",
      "citation": "Rasendran et al., J Glaucoma 2022, abstract",
      "limit": "Whitepaper POAG population transport and phenotype mismatch remain provisional.",
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      "name": "Inflammatory bowel disease",
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      "kind": "annual",
      "basis": "Annual patient-minus-control paid claims",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7534391/",
      "citation": "Park et al., IBD 2020, Results / Figure 2",
      "limit": "Dollar year 2016 used as a normalization assumption, not verified. Cost difference is observational.",
      "social": 2000,
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      "name": "Gout",
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      "continuing": 0,
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      "basis": "Adjusted annual excess all-cause medical expenditure",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10437756/",
      "citation": "Wu et al., JMCP 2008, Results",
      "limit": "Older insured cohort; residual comorbidity attribution possible. Whitepaper sex/population pairing provisional.",
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      "family_baseline": 0.11871634299962144,
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      "name": "Basal cell carcinoma",
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      "year": 2018,
      "duration": 3,
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      "kind": "annual",
      "basis": "Nonmelanoma skin-cancer treatment cost proxy",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11001479/",
      "citation": "Kao et al., Cancer Causes Control 2023, Table 1",
      "limit": "Includes squamous cell cancer; not a BCC-only estimate. Three treatment years is an analyst assumption.",
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      "name": "Testicular cancer",
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      "continuing": 0,
      "year": 2013,
      "duration": 1,
      "onset": 35,
      "kind": "episode",
      "basis": "Early-stage seminoma treatment and surveillance scenario",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4298389/",
      "citation": "Aberger et al., Cancer Medicine 2014, Abstract",
      "limit": "Stage-specific modeled cost, not average lifetime cost; 2013 normalization year assumed. No population RRR supplied.",
      "social": 0,
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      "family_baseline": 0.02369802320739443,
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      "name": "Hypertension",
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      "sex": 1,
      "cost": 1920,
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      "duration": 25,
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      "basis": "Adjusted annual incremental healthcare expenditure",
      "url": "https://pubmed.ncbi.nlm.nih.gov/29848493/",
      "citation": "Kirkland et al., JAHA 2018, abstract",
      "limit": "2014 normalization year assumed from end of observation window; not independently verified.",
      "social": 0,
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      "family_baseline": 0.47950048598359346,
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      "name": "Multiple sclerosis",
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      "continuing": 0,
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      "duration": 30,
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      "kind": "annual",
      "basis": "Annual excess direct medical costs",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9109149/",
      "citation": "Bebo et al., Neurology 2022, Table 2",
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      "social": 22520,
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      "family_baseline": 0.034334514202719525,
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      "name": "Breast cancer",
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      "continuing": 4372.4,
      "year": 2020,
      "duration": 10,
      "onset": 60,
      "kind": "initial_plus",
      "basis": "First year plus continuing medical and oral drug costs",
      "url": "https://progressreport.cancer.gov/after/economic_burden",
      "citation": "NCI / Mariotto et al., site and phase tables",
      "limit": "Female model only; 50% cohort sex share assumed without selecting sex. Terminal care excluded.",
      "social": 0,
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      "family_baseline": 0.1984045041477807,
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    {
      "name": "Psoriasis",
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      "year": 2019,
      "duration": 30,
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      "kind": "annual",
      "basis": "Annual matched patient-minus-control all-cause costs",
      "url": "https://pubmed.ncbi.nlm.nih.gov/33934270/",
      "citation": "Merola et al., Clin Rheumatol 2021, abstract",
      "limit": "Uses psoriasis without psoriatic arthritis; observational cost difference.",
      "social": 0,
      "r2": 0.0928,
      "cpi": 255.657,
      "family_baseline": 0.11178442845710271,
      "family_selected": 0.06590634825561004,
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    },
    {
      "name": "Melanoma",
      "k": 0.02975,
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      "continuing": 3019.1,
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      "basis": "First year plus continuing medical and oral drug costs",
      "url": "https://progressreport.cancer.gov/after/economic_burden",
      "citation": "NCI / Mariotto et al., site and phase tables",
      "limit": "Medicare-derived costs; terminal care excluded; not current advanced-drug pricing.",
      "social": 0,
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      "family_baseline": 0.09625116145119927,
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    {
      "name": "Osteoporosis",
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      "continuing": 0,
      "year": 2021,
      "duration": 10,
      "onset": 65,
      "kind": "annual",
      "basis": "Adjusted annual marginal healthcare expenditure",
      "url": "https://pubmed.ncbi.nlm.nih.gov/39706294/",
      "citation": "Marginal health care expenditures, JAPhA 2025, abstract",
      "limit": "2021 normalization year assumed. Whitepaper K is a model input, not validated US birth-cohort lifetime incidence.",
      "social": 0,
      "r2": 0.0573,
      "cpi": 270.97,
      "family_baseline": 0.3931583524307207,
      "family_selected": 0.3140177413168526,
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  ],
  "cpi": {
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    "2010": 218.056,
    "2013": 232.957,
    "2014": 236.736,
    "2016": 240.007,
    "2018": 251.107,
    "2019": 255.657,
    "2020": 258.811,
    "2021": 270.97,
    "2022": 292.655,
    "2024": 313.689
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  "paper": "https://reticular.com/blog/embryo-complete-whitepaper",
  "risk_csv": "https://reticular.com/blog/embryo-complete-whitepaper/assets/family-risk-results.csv",
  "cpi_url": "https://www.bls.gov/cpi/tables/supplemental-files/historical-cpi-u-202412.pdf",
  "asof": "2026-11-09"
}