Built around your history3 recurrent first-trimester lossesNo genetic testing of the lossesConceiving naturally — no IVF
Two inherited findings — one may help explain your losses
After three losses, this report is meant to help make sense of what happened. It looked for inherited genetic changes that the usual miscarriage tests don't check — in genes that affect egg and sperm quality and how an embryo develops in its first days. Two came back for the two of you to review together.
MMaya · 2 genetic changes foundDDaniel · No genetic changes found
2:10
Guided sample report
A genetic counselor walks through a sample report
Christina explains how to read the main finding, partner results, counselor context, and possible next steps.
Educational example only. Your results and next steps will depend on your history and care team.
Read the walkthrough summary
01Start with the report summary: it highlights the findings most relevant to the couple’s history without treating them as a diagnosis.
02Compare each partner’s results, then open an individual finding to see the evidence, inheritance pattern, and plain-language interpretation.
03Use Christina’s counselor note to separate the result that may help explain the losses from lower-risk carrier information.
04Bring the result and suggested next steps to a reproductive genetics specialist or genetic counselor for decisions specific to your history.
Partner results
Select any finding below to open its full explanation — what the change is, the evidence, how it's inherited, and what it does and doesn't mean.
M
Maya
Egg source
Higher risk
2 genetic changes found
One higher-risk change (TUBB8) that could help explain the losses, and one carrier change (DHCR7) that's low-risk here because Daniel screened clear.
Note: The TUBB8 finding is the one to act on; the DHCR7 carrier result is information to keep on file, not a risk today.
D
Daniel
Sperm source
No known risks
No genetic changes found
Daniel's results came back clear in every category — genuinely good news, and it helps focus the picture on the TUBB8 finding your team can act on.
No genetic changes were found in any category on the panel.
Christina's counselor note
Reviewed by Christina, Genetic Counselor
What we found
Maya carries a harmful change in the TUBB8 gene — a gene that works inside the egg (doctors call this “maternal-effect”) and shapes how eggs mature and embryos start to grow.
It's the kind of finding that can help explain repeated early losses the usual tests haven't.
None of this is something you did — nothing about how you tried to conceive caused these losses.
Why it matters
When losses are tested and the chromosomes come back normal, about 1 in 4 still have an inherited cause the usual tests miss.
It turns an “unexplained” loss into something you can plan around.
The DHCR7 carrier finding
DHCR7 is a carrier result (one changed copy, one normal) — it does not explain your losses and does not affect your health.
Because Daniel screened clear, the risk to a pregnancy is low.
What's next
Speak with a reproductive genetics specialist about the TUBB8 finding.
Ask about IVF, which can screen embryos for this change — a common next step after recurrent loss.
Now there's a concrete next step to take with your care team.
What you can do next
A positive panel is a starting point, not a verdict. These are the options most couples discuss after a result like this.
Confirm it with a specialist
Review the TUBB8 finding with a reproductive genetics specialist or genetic counselor to confirm it and interpret it for your situation.
What a positive result does not mean for a healthy pregnancy
A positive result does not mean a child from an ongoing, healthy pregnancy will be affected.
This change acts on the egg, not the baby
TUBB8 works in the egg and earliest embryo, not in a growing baby.
A carrier copy doesn't cause loss
One copy of a recessive gene like DHCR7 doesn't cause pregnancy loss — a condition needs a damaged copy from both parents.
It tests parents, not a pregnancy
This is a pre-conception panel — not a prenatal or newborn test.
What the panel screens
750+ genes
grouped by biological mechanism
Grouped by what each gene does in reproduction. Both partners are checked in every group; only genetic changes worth reporting show above.
Genes that help the egg mature and divide
~96 genes on the panel
1 finding · Maya (TUBB8)
These genes help an egg finish maturing and line up its chromosomes to divide. A fault — TUBB8 is the classic example — can leave eggs unable to mature or embryos stalling in the first few days, before a pregnancy can take hold.
TUBB8PATL2TRIP13TACC3
Genes for fertilization
~34 genes on the panel
No findings
These genes handle fertilization — the egg's outer coat (the zona pellucida) and the signal sperm use to switch the egg on. A fault can cause fertilization to fail even when the egg and sperm look normal.
WEE2PLCZ1ACTL7AACTL9
Genes that run the embryo's first days
~52 genes on the panel
No findings
The egg stores a “starter kit” of genes that run the embryo's first divisions. A fault makes embryos stop growing at the same early stage, cycle after cycle — a signal that points to egg biology, not anything either of you did.
BTG4CHEK1TLE6PADI6
Genes tied to molar pregnancy
~14 genes on the panel
No findings
These genes set the maternal “imprint” (a chemical tag on the egg's genes) that an embryo needs. A fault can cause molar pregnancies — abnormal tissue growth instead of a healthy pregnancy — and repeat losses that trace to egg biology, with any partner.
NLRP7KHDC3LMEI1TOP6BL
Genes an embryo needs to survive and grow
~386 genes on the panel
1 carrier · Maya (DHCR7)
Genes an embryo needs simply to survive and grow, drawn from the 934-gene Human Intolerome. If both partners carry a fault in the same gene, about 1 in 4 embryos can be affected — a cause standard chromosome testing can't see.
DHCR7PKHD1RYR1NEB
Blood-clotting & pregnancy-support genes
~22 genes on the panel
No findings
Clotting and pregnancy-support genes — like Factor V Leiden (F5) — that can raise the risk of later loss. Their link to early loss is weaker and depends on the whole clinical picture.
F5F2MTHFRSERPINC1
Genes for sperm
~154 genes on the panel
No findings
Genes for making and shaping sperm. A fault can lower the count, slow movement, or change shape — and helps show whether a lab step that injects a single sperm into an egg (called ICSI), or another step, would help.
CFTRAURKCDPY19L2DNAH1
The survival genes come from a published list of 934 genes an embryo needs to grow (researchers call it the Human Intolerome). Lists show a representative subset, not the full panel.
