Reticular · Embryo Report · Core

Sample report

Nadia and Theo's embryo report

5 embryos reviewed · chromosome results and viability genes

Every embryo, at a glance.

No known risks
Moderate risk
Higher risk

Chromosome result and viability-gene review for each embryo
Result	Embryo 4E-4AA-7F3C	Embryo 2E-5AB-2A91	Embryo 7E-5BA-4C26	Embryo 6E-4BA-8D42	Embryo 5E-3BB-1C57
Chromosomes	Euploid	Euploid	Euploid	Low-level mosaic	Aneuploid
Viability genes	No known risks No finding	Moderate risk F5c.1601G>A	Higher risk TUBB8c.686T>C	Higher risk TUBB8c.686T>C	Higher risk Not assessed
Embryo grade	4AADay 5 blastocyst	5ABDay 5 blastocyst	5BADay 5 blastocyst	4BADay 5 blastocyst	3BBDay 6 blastocyst
Sex	Female46,XX	Male46,XY	Male46,XY	Female46,XX	Male46,XY

Where the chromosome result already explains the risk, viability genes are not separately assessed. Sex is reported, never ranked.

Clinical summary

Embryo 4 is the best fit to transfer first: euploid, with no reportable pregnancy-loss gene finding.

Three of these five embryos are chromosomally normal, and only Embryo 4 is also clear on the viability genes. The order below follows the chromosome result first, then the viability-gene review, then grade.

A suggested order, not a transfer decision. A finding does not mean an embryo will fail, and a clear result does not guarantee a transfer will succeed — grade, your history, and your clinic's judgment all belong in the call. Nothing either of you did caused these findings.

Inherited variants

What you both carry.

Both partners were sequenced across the panel. These are the reportable findings, with the embryos each was seen in — the per-embryo review below says what each one means for that embryo.

TUBB8
Published reproductive evidence
Higher risk
A published TUBB8 variant was identified in a gene with strong evidence for oocyte maturation problems and early embryo arrest, so the finding may be relevant to reproductive counseling. Maternal-effect / oocyte biology.
- Nadia
  Egg source
  c.686T>C (p.Val229Ala)
  Known to be harmful (pathogenic)
  Carrier
- Theo
  Sperm source
  Not detected
  No reportable variant in this gene
  Not detected
Reported in: Embryo 7 and Embryo 6.
The variant
TUBB8 c.686T>C (p.Val229Ala)
PathogenicPublished reproductive evidence
Evidence
TUBB8 c.686T>C (p.Val229Ala) is listed in ClinVar as pathogenic for oocyte maturation defect 2. The cited NEJM report describes dominant oocyte maturation defects and functional disruption of microtubules.
What it means here
This is a published variant in a gene with stronger reproductive evidence, and it may affect early embryo development. Your Reticular genetic counselor reviews what it means for this embryo's place in the ranking.
What it doesn't mean
It doesn't predict a future child's health — TUBB8 acts on the egg, not the child — and it doesn't guarantee this embryo will fail. It flags a higher chance of early arrest to weigh alongside your chromosome result and embryo grade.
References
- ClinVar: TUBB8 p.Val229Ala
- Feng et al., NEJM 2016
F5
Known variant, limited pregnancy-loss evidence
Moderate risk
A known F5 variant was identified, but the published pregnancy-loss evidence is limited and context-dependent. Weigh it against your full fertility history — your Reticular genetic counselor can help you put it in perspective. Autosomal dominant thrombophilia variant.
- Nadia
  Egg source
  Not detected
  No reportable variant in this gene
  Not detected
- Theo
  Sperm source
  c.1601G>A (Factor V Leiden)
  Known to be harmful (pathogenic)
  Carrier
Reported in: Embryo 2.
The variant
F5 c.1601G>A (Factor V Leiden)
PathogenicKnown variant, limited pregnancy-loss evidence
Evidence
This panel separates variant classification from reproductive evidence. F5 c.1601G>A (Factor V Leiden) is a known pathogenic variant, but GeneReviews frames heterozygosity as at most a weak contributor to recurrent or late pregnancy loss.
What it means here
This is a known variant, but its relevance to this specific embryo is limited. On its own it does not change which embryo is the best fit — it is a moderate-risk finding to keep in context, not a cause of pregnancy loss.
May affect your own health
Factor V Leiden is a clotting (thrombophilia) variant, so it can matter for your own health more than for this embryo — it raises the risk of blood clots (DVT/PE), especially during pregnancy or on hormonal medication. Most carriers have healthy pregnancies. Worth reviewing with your own physician, separately from embryo selection.
What it doesn't mean
This finding is not the proven cause of a pregnancy loss and does not predict that an embryo will fail. It is context, not a verdict — your included counseling session can put it in perspective.
References

Results by embryo

Embryo prioritization based on results.

Best fit · Suggested order
Embryo 4
E-4AA-7F3C · Day 5 blastocyst
EuploidNo known risksGrade 4AAFemale
Transfer Embryo 4 first — the only embryo in this cohort that is euploid with no reportable pregnancy-loss gene finding.
No high-priority inherited findings were identified in the curated set of genes associated with pregnancy loss and embryonic viability.
Fit 2 · Suggested order
Embryo 2
E-5AB-2A91 · Day 5 blastocyst
EuploidModerate riskGrade 5ABMale
Embryo 2 is next: also euploid, and its F5 finding rests on evidence too limited and context-dependent to move it down the list.
- F5
  F5 c.1601G>A (Factor V Leiden)
  Moderate risk
  Inherited
  Heterozygous
Fit 3 · Suggested order
Embryo 7
E-5BA-4C26 · Day 5 blastocyst
EuploidHigher riskGrade 5BAMale
Embryo 7 sits behind the other two euploid embryos because of a published TUBB8 variant tied to early embryo arrest — the kind of finding a chromosome count cannot see.
- TUBB8
  TUBB8 c.686T>C (p.Val229Ala)
  Higher risk
  Acts through the egg
  Acts through the egg, not the embryo's own copy
Fit 4 · Suggested order
Embryo 6
E-4BA-8D42 · Day 5 blastocyst
Low-level mosaicHigher riskGrade 4BAFemale
Consider Embryo 6 only after all three euploid embryos: a low-level mosaic result and the same higher-risk TUBB8 variant add uncertainty on two fronts.
- TUBB8
  TUBB8 c.686T>C (p.Val229Ala)
  Higher risk
  Acts through the egg
  Acts through the egg, not the embryo's own copy
Lower fit · Suggested order
Embryo 5
E-3BB-1C57 · Day 6 blastocyst
AneuploidHigher riskGrade 3BBMale
Embryo 5 is the lowest priority here, because whole-chromosome aneuploid embryos rarely lead to a healthy live birth.
PGT-A detected aneuploidy in this embryo. That chromosome result is the primary viability concern in this report.

What Core screened

Genes reviewed in every embryo.

Grouped by what each gene does in embryo viability and pregnancy loss, with every group's gene list shown in full and counted exactly. Both partners are screened across the wider 750+ gene panel; the groups below are the ones reviewed in each of your embryos.

Genes that help the egg mature and divide

18 genes · full list

TUBB8 · 2 embryos

These genes help an egg finish maturing and line up its chromosomes to divide. A fault — TUBB8 is the classic example — can leave eggs unable to mature or embryos stalling in the first few days, before a pregnancy can take hold.

TUBB8PATL2TRIP13TACC3CDC20KIF11TUBA4AKIF18AHAUS6LHX8TBPL2ZFP36L2

Gene list sources: ESHRE FeRGI Database · Curated published literature

Genes for fertilization

10 genes · full list

No findings

These genes handle fertilization — the egg's outer coat (the zona pellucida) and the signal sperm use to switch the egg on. A fault can cause fertilization to fail even when the egg and sperm look normal.

ZP1WEE2PLCZ1ZP2ZP3ZP4ASTLACTL7AACTL9IZUMO1R

Gene list sources: ESHRE FeRGI Database · Curated published literature

Genes that run the embryo's first days

12 genes · full list

No findings

The egg stores a “starter kit” of genes that run the embryo's first divisions. A fault makes embryos stop growing at the same early stage, cycle after cycle — a signal that points to egg biology, not anything either of you did.

PADI6TLE6NLRP5NLRP2BTG4CHEK1OOEPKPNA7MOSFBXO43MEI4PANX1

Gene list sources: ESHRE FeRGI Database · Curated published literature

Genes tied to molar pregnancy

5 genes · full list

No findings

These genes set the maternal “imprint” (a chemical tag on the egg's genes) that an embryo needs. A fault can cause molar pregnancies — abnormal tissue growth instead of a healthy pregnancy — and repeat losses that trace to egg biology, with any partner.

NLRP7KHDC3LMEI1TOP6BLREC114

Gene list source: ESHRE FeRGI Database

Genes a pregnancy needs to keep growing

182 genes · full list

No findings

Genes an embryo needs to keep developing through pregnancy, from the published Human Intolerome. Where both partners carry a fault in the same gene, Core checks which of your embryos inherited both copies — a cause of loss that chromosome testing cannot see.

AAASABCB4ABCC6ACO2ACTA1ACTG2ADAMTS2ADGRG6ADSLAGKAGTAGTR1

Gene list source: RPLdb Human Intolerome

Blood-clotting & pregnancy-support genes

12 genes · full list

F5 · Embryo 2

Clotting and pregnancy-support genes — like Factor V Leiden (F5) — that can raise the risk of later loss. Their link to early loss is weaker and depends on the whole clinical picture.

F5F2SERPINC1PROCPROS1ANXA5NOS3SERPINE1F13A1THBDFGAFLT1

Gene list sources: ESHRE FeRGI Database · Curated published literature

Every embryo, at a glance.

Embryo 4 is the best fit to transfer first: euploid, with no reportable pregnancy-loss gene finding.

What you both carry.

Published reproductive evidence

Known variant, limited pregnancy-loss evidence

Embryo prioritization based on results.

Embryo 4

Embryo 2

Embryo 7

Embryo 6

Embryo 5

Genes reviewed in every embryo.

Genes that help the egg mature and divide

Genes for fertilization

Genes that run the embryo's first days

Genes tied to molar pregnancy

Genes a pregnancy needs to keep growing

Blood-clotting & pregnancy-support genes