Beyond PGT-A: how Embryo Core uses existing embryo data

A chromosome result is one part of the picture

A euploid PGT-A result means the tested sample was classified as having the expected chromosome complement within the test's limits. It does not mean every gene has been checked, and it cannot promise a successful pregnancy. PGT-A generally looks for chromosome-number changes and larger gains or losses of chromosome material. Smaller changes within individual genes ask a different testing question.

If you are trying to understand a previous result, start with our guide to what a normal PGT-A result means.

What the research asks—and what it cannot answer yet

Sean's article discusses research into possible single-gene contributors to recurrent pregnancy loss after chromosome testing has not explained the losses. The study examined pregnancy-loss tissue and parental samples; it was not a trial of Reticular or of embryo selection using Embryo Core.

The cited work is a preprint. Its findings do not establish that additional embryo analysis improves live-birth rates, or that a finding explains a particular person's loss. Read the original study and its methods alongside Sean's discussion of the limitations.

Where Embryo Core fits

Embryo Core combines both partners' genetic data with compatible raw PGT-A data from embryos you already have. The aim is to assess inheritance of relevant parental variants in those embryos and present the findings alongside their chromosome results. No new embryo biopsy is required for compatible existing data.

Core focuses on fertility and pregnancy-loss genes. It does not include polygenic scores or trait predictions. Reticular also offers Embryo Complete, a separate, broader report. The research discussed here should not be read as validation of either product's ability to improve pregnancy outcomes.

How Embryo Core works with existing PGT-A data

Embryo Core starts with the results you already have and adds a review of relevant parental variants. The process has four steps:

1. Request the underlying PGT-A file. Reticular provides a lab-specific request you can send to your clinic or testing lab. A PDF chromosome report alone is not the raw embryo data needed for this analysis.
2. Confirm compatibility before paying. Reticular checks whether the lab's data supports the analysis. Not every platform or file is compatible.
3. Screen both partners at home. The package includes two saliva kits and screening across 750+ reproductive genes. Compatible markers in each embryo's existing data help assess which relevant parental variants it inherited; no new biopsy is needed.
4. Review the report together. The report places each assessed embryo's viability-gene findings beside its chromosome result. A genetic counselor explains the findings and helps you prepare questions for your fertility clinician.

If you do not have embryos or compatible embryo data, the Infertility & Pregnancy Loss Panel is a different starting point: testing one or both partners without IVF.

How to use the report

Review findings with a genetic counselor and your fertility clinician. Ask what was assessed, how strong the evidence is, which results are uncertain, and whether any finding needs further testing. A report can support that conversation; it cannot explain every loss or guarantee a transfer outcome. A result with no reportable finding does not rule out all genetic causes.